Assessment of Hepatoprotective and Nephrototective Activity of Punica grantum and Bryophyllum calycinum Gentamicin Induced in Experimental Rats Model

Abstract

Objective: Our research work aim was the assessment of hepatoprotective and nephrototective activity of Punica grantum and Bryophyllum calycinum gentamicin induced in experimental rats’ model.

Methods: Punica grantum and Bryophyllum calycinum herbal aqueous extract of hepatoprotective and nephrotoxicity activity was determined using the gentamicin induced hepatotoxicity and nephrototective in experimental rats model. Rat models were administered a Punica grantum and Bryophyllum calycinum herbal aqueous extract in doses of 100 and 500 mg/kg for a weeks. The biochemical parameters and histopathological evaluations parameters were used for estimation of hepatoprotective and nephrototective activity of Punica grantum and Bryophyllum calycinum.

Result: The findings of all these evaluation parameters showed that Punica grantum and Bryophyllum calycinum herbal aqueous extract have the potential hepatoprotective and nephrototective activity.

Conclusions: Punica grantum and Bryophyllum calycinum herbal aqueous extract could be used for the treatment and management of hepatopro toxicity and nephrotoxicity.