The Effect of Intermittent Topical Insulin Application on Diabetic Wound Healing

Abstract

Delayed wound healing in diabetics is one of the most common problems faced by patients and health care providers. Injuries to the extremities are a formidable problem in patients suffering from diabetes mellitus. The prolonged treatment and associated morbidity must be addressed by early wound healing. In this study 54 patients with diabetic wounds of the foot were included and randomized into study and control groups. The maximum length and width of the ulcer were measured, and the area was calculated. In group A, insulin is used in a solution of normal saline in the dose of 0.4 units per cm2 area of the wound on day 0, 3, 6, 9 and 12. In group B, standard dressings with saline were performed. Measurements were taken on day 15 and compared with day 0 and the percentage of reduction in the size of the wound arrived at. The average percentage reduction of wound size in group A was more than that of group B, inferring accelerated wound healing on topical insulin therapy. It was also observed that the wound healing was more rapid in younger participants as compared to older participants and better healing in those who did not have other co-morbid illnesses when compared to participants who had at least one comorbid illness apart from diabetes.

Trial registration number: CTRI/2021/05/033671 (Registered on 18/05/2021).