Optimizing Pulmonary Arterial Hypertension Pharmacotherapy In The Intensive Care Unit: A Guide To Management Considerations
Keywords:
Pulmonary arterial hypertension; intensive care unit; enteral administration.Abstract
Pulmonary arterial hypertension is a rare and progressive disease associated with significant morbidity and mortality risks. There are several approved medications that target three major disease pathways for treatment. However, managing pulmonary arterial hypertension pharmacotherapies in a patient admitted to an intensive care unit presents distinct challenges. Factors such as intubation and altered mental status may hinder the continuation of home oral and/or inhaled therapy, and disease progression may necessitate therapy escalation. This review will primarily address practical strategies for the ongoing administration of home pulmonary arterial hypertension pharmacotherapy and therapy escalation.