A fast and sensitive spectrophotometric method for the determination of hydrazine in atazanavir sulfate drug substance

Abstract

This abstract introduces an analytical methodology that has been developed the determination of hydrazine in atazanavir sulfate drug substance. The proposed technique was motivated by the rising need for analysis of the reported genotoxic structural concerns, such as hydrazine, and consequently the quantification by a cost-effective manner. Atazanavir's active ingredient, hydrazine, was coupled with p-dimethylaminobenzaldehyde (DMAB) in an acidic medium to provide the basis for this technique. This technique is advantageous because to its high sensitivity, narrow selectivity, speed, and cheap cost per analysis.