Development And Evaluate Nanoparticles Of Poorly Soluble Anti-Diabetic Drug (Pioglitazone) Loaded Tablets

Abstract

Diabetes mellitus is a pervasive metabolic disorder that poses a substantial global health burden. The treatment of Type 2 Diabetes (T2D), characterized by insulin resistance and impaired glucose metabolism, often involves the use of oral anti-diabetic medications, such as Pioglitazone (PGZ). Nanoparticle-based drug delivery systems have emerged as a promising avenue for improving the solubility and bioavailability of poorly water-soluble drugs. The encapsulation of PGZ within nanoparticles provides an opportunity to achieve controlled drug release, targeted delivery, and enhanced therapeutic outcomes.The significance of enhancing PGZ solubility lies in the potential for improved therapeutic efficacy, dose reduction, enhanced patient compliance, and targeted drug delivery. In this study, the practically water-insoluble PGZ was nanoground by using nanosuspension by precipitation method. Tween 80 Emulsifier surface active agents were tested for their stabilizing effects. Formulation factors evaluated were ratio of polymer to drug, whereas process parameters were milling time and concentration of PGZ beads. Different concentration of surfactant such as Tween 80 and ethanol: distilled water aqueous phase combination of surfactant was used for preparation of PGZ nanosuspension. Responses measured in this study include particle size measurement, zeta potential and Yield Percentage. The outcomes of this research hold promise for revolutionizing PGZ therapy, offering an avenue to enhance its solubility and bioavailability, and ultimately improve patient outcomes and quality of life.