Insilico Study of Tridax Procumbens Compounds as Potential Therapeutics Against Wound healing and Anticancer infection

Abstract

Tridax procumbens is an adaptable plant with promising phytoconstituents, interesting medicinal uses, and nutritional importance. This exploratory study seeks to dock the active components of Tridax procumbens, a natural plant with several pharmacological and biological properties. Hence, the possibilities of the best-described Tridax procumbens phyto compounds of powerful Wound healing and Anticancer inhibitors have been attempted in this investigation. All phytoconstituents were subjected to molecular docking studies for the inhibition of glycogen synthase kinase 3-b (GSK3-b) protein, a main target for wound healing activity by Wnt signaling pathway. Molecular docking study was performed for these Tridax procumbens phyto compounds to evaluate and analyze the anti-lymphoma cancer activity. Molecular docking score and the rank revealed the bonding affinity towards the site of interaction of the on coprotein anaplastic lymphoma kinase (ALK). These potential drugs with higher affinity for the targets of (GSK3-b) protein and (ALK) proteins and adequate absorption, distribution, metabolism, excretion, and toxicity (ADMET) values are candidates for treating or preventing Wound healing and Anticancer infections. In vitro and in vivo investigations are needed to evaluate further the efficacy and toxicity of these hit compounds.