Study on various biomarker levels and outcome in patients of SARS-CoV-2 infection: a retrospective study in tertiary care
Keywords:
SARS-CoV-2 infection, d-dimer, serum albumin, C-reactive protein, serum ferritin, lactate dehydrogenase, vitamin D, biomarkerAbstract
Background: SARS-CoV-2 infection was classified as a pandemic by the World Health Organization on March 11, 2020, with a confirmed case count currently exceedingly more than 100 million people. We aim to explore correlation and outcome of various biomarkers with severity of illness in patients with SARS-CoV-2 infection and to study serial biomarker levels in patients with SARS-CoV-2 infection admitted in Maharishi Markandeshwar and Medical College and Hospital, Solan, Himachal Pradesh, India.
Material and methods: We retrospectively analyzed the serial biomarker levels during admission and their correlation and outcome in SARS-CoV-2 infection of total 90 cases in Maharishi Markandeshwar and Medical College and Hospital, Solan from 1 Dec,2021 to 28 feb,2022 after approval from Institutional Ethics Committee.
Results: Chi square test analyzed that 100% of patients with reduced serum ferritin (P=0.000) and LDH (P=0.000) levels at arrival were associated with poor outcome. Moreover 66.67% of patients with elevated D-Dimer (P=0.000), hypoalbuminemia 75% with (P=0.017) and 33.33% associated with CRP positive (P=0.000) on admission were not improved clinically.
Conclusion: Elevated d-dimer levels, hypoalbuminemia, CRP positive, raised serum ferritin levels, increased lactate dehyrogenase level were related with poor outcome of SARS-CoV-2 infection whereas vitamin D levels didn’t play significant role in predicting severity and outcome of disease in COVID 19 patients.
