“ Clinical and microbiological evaluation of efficacy of SRP alone and in combination with LDD and mouthwash against P.gingivalis in patients with periodontitis.”

Abstract

Background: Scaling and Root Planning (SRP) is the gold standard non-surgical periodontal treatment, but mechanical debridement alone may fail to eliminate the putative pathogens. The selective removal or inhibition of pathogenic microbes specially P.gingivalis with systemic or locally delivered antimicrobial and host modulating agents, in combination with SRP, is often considered as an effective approach at specific disease active sites. So, present study was conducted to evaluate efficacy of scaling and root planing (SRP) alone or in combination with LDD or tetracycline mouthwash against P. gingivalis in patient with chronic periodontal disease.

Materials and methods: The present study was conducted in the Department of Periodontology, S.G.T Dental college in collaboration with Department of Biotechnology, Chaudhary Devi Lal University (CDLU), Sirsa. Clinical parameters recorded were Simplified Oral hygiene Index (SOHI), Plaque Index (PI), Gingival Index (GI), Periodontal Pocket Depth (PPD). All clinical parameters were measured at 0 (baseline), 21st and 42nd days and recorded. Division of groups:  The patients were randomly divided into 3 groups as follows: Group I: 50 pts – SRP, Group II: 50 pts - SRP with LDD (Tetracycline fibers - Periodontal Plus AB), Group III: 50 pts - SRP with Mouthwash (Tetracycline mouthwash - Formulated). For each assessment point, data were statistically analyzed using one way ANOVA. The level of significance was set at p < 0.05.

Results: A statistically significant difference in OHIS, GI and PI at 21 and 42 day but results at baseline was not significant. A statistically significant difference in PPD at 42 day but results at baseline and 21st day were not significant. A statistically significant difference in CFU of P.gingivalis at 21 and 42 day but results at baseline was not significant. It also depicts that mean value of CFU of P.gingivalis were comparatively lowest in Group II followed by Group III and least reduction from baseline to 42th day was noted in Group I.

Conclusion: The result of study showed that Group II resulted in better optimum clinical results in comparison to the other two treatment groups, i.e.  Group III and Group I.