A Comprehensive Review of Disintegrants: Backbone of disintegration

Abstract

Strong attractive bonding forces works among the particles of solid dosage forms such as mechanical, solid and intermolecular and bioavailability of solid dosage form is preferentially dependent on in vivo disintegration then dissolution. This review is focused for disintegrating agents, their categories, mechanisms of action, associated pros and cons. Furthermore, more emphasis is on natural superdisintegrants, those perform disintegration at fastest rate with limited side effects. So, they are in frequent use to create number of preparations like fast dissolving tablet, pulsatile and tablet dispersible tablet etc. Despite of various disintegrants, superdisintegrants co-processed form of them are thoroughly investigated along with novel techniques of production such as Melt Extrusion, Crystallization, Spray Drying, Solvent Evaporation, Granulation/ Agglomeration.