Synthesis and biological evaluation of Schiff bases from substituted 1,3, 4 Thiadiazole as multi-functional agents with antimicrobial and antioxidant activities

Abstract

Schiff bases have gradually evolved into powerful biological agents because of their biological and medicinal properties. In this work, an efficient method is developed for the synthesis of Schiff bases from substituted 1,3,4 Thiadiazole. All the synthesized molecules were characterized using various spectral techniques including FTIR, 1HNMR,13CNMR, and Mass spectrometry.All the new synthesized compounds were then screened for their antimicrobial activity against three types of bacteria and three fungal strains, by application of the MIC assays. The antioxidant activities were also estimated and strongly correlated with the potential of BHT or butylated hydroxy toluene. All the synthesised compounds showed good antimicrobial activity at concentrations ranging between at 1–2.25 g/mL. The synthesised compounds also showed promising antioxidant activities, as compared with BHT, with 3b, 3d, and 3h showing appreciable antioxidant efficacy.