Gram Negative Bacterial Resistance to Ciprofloxacin and Levofloxacin in Inpatient Hospital Setting in Alkharj, Saudi Arabia

Abstract

Gram-negative bacteria can acquire resistance to antibiotics classes that are usually effective
against them such as the third- or fourth-generation cephalosporins and fluoroquinolones. The infections
that are caused by antimicrobial-resistant organisms lead to treatment failure, increases cost of medical
therapy, increase in socioeconomic burden and increases hospitalization stay. This study aims to determine the sensitivity of Gram-negative bacteria to ciprofloxacin and levofloxacin in an inpatient setting of
public hospital in Alkharj. The resistance of several Gram negative bacteria especially Acinetobacter and
Providencia to ciprofloxacin and levofloxacin is high. It is important to increase the awareness regarding
the use of these medications and it is important to implement interventions to decrease the inappropriate
use of quinolones. In addition to that more interventions are required in order to decrease the bacterial resistance such as to take into consideration the patient characteristics including the kidney and liver function status.